PostEra is the first company to algorithmically complete the ‘design-make-test’ cycle of drug discovery. Our machine learning methods iteratively design the best drug candidates, decide how to make them, and test the compounds using the most informative experiments. With this new technology, we can search new areas of chemical space hitherto unexplored. Furthermore, incorporation of model uncertainty allows our algorithms to be aware of their own limitations, allowing for safer and more cost-effective predictions when compounds must be synthesised and experimentally verified. Ultimately, these novel approaches allow us to industrialise the traditionally artisanal field of drug discovery.